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Constitutive reduction in the checkpoint inhibitor, CTLA-4, does not accelerate SLE in NZM 2328 mice

Background/objective Treatment with immune checkpoint inhibitors (ICIs) in oncology patients is increasing. Although ICIs trigger rheumatic immune-related adverse events, development of SLE features has been rare. Whether long-term treatment with ICIs would promote SLE features remains unknown. To b...

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Detalhes bibliográficos
Principais autores: William Stohl, Chaim Putterman, Ning Yu, Samantha A Chalmers, Chaim O Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019-12-01
Colecção:Lupus Science and Medicine
Acesso em linha:https://lupus.bmj.com/content/6/1/e000313.full
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