HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.

The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase. Here, we identified two transcriptional regulators, ZIP and sZIP, as Vpr-binding proteins d...

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Detalhes bibliográficos

Principais autores:	Claire Maudet, Adèle Sourisce, Loïc Dragin, Hichem Lahouassa, Jean-Christophe Rain, Serge Bouaziz, Bertha Cécilia Ramirez, Florence Margottin-Goguet
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-01-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3792905?pdf=render
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