The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

Abstract There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a central pathophysiological feature of TBI. NLRP3 inflammasome activity is a necessary component of the innate...

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Hlavní autoři:	William T. O’Brien, Louise Pham, Georgia F. Symons, Mastura Monif, Sandy R. Shultz, Stuart J. McDonald
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-04-01
Edice:	Journal of Neuroinflammation
Témata:	Neuroinflammation TBI Concussion Mild traumatic brain injury Chronic traumatic encephalopathy Microglia
On-line přístup:	http://link.springer.com/article/10.1186/s12974-020-01778-5
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