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Dose- and Organ-Specific Dual Effects of MitoTempo in Paracetamol-Induced Hepatorenal Toxicity in Mice

Paracetamol (PAR) overdose is a major cause of drug-induced liver injury and is also associated with renal toxicity, both involving mitochondrial dysfunction and oxidative stress. This study investigated the dose- and organ-specific effects of the mitochondria-targeted antioxidant MitoTempo (MT) on...

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Principais autores: Hilmi Orhan, Kemal Atmaca, Berin Aladağ, Mustafa Kotmakçı
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-04-01
coleção:Biomolecules
Assuntos:
paracetamol
mitotempo
hepatotoxicity
nephrotoxicity
mitochondria
oxidative stress
Acesso em linha:https://www.mdpi.com/2218-273X/16/4/556
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