Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

Summary: While a few works have shown that Mettl3 plays oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis remains unclear. In Mettl3flox/flox; Alb-Cre knockout mice, Mettl3 loss leads to aberrant hepatocyte homeostasis and liver damage. Importantly, Mettl3 de...

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Bibliografische Detailangaben

Hauptverfasser:	Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-07-01
Schriftenreihe:	Cell Reports
Schlagworte:	liver cancer Mettl3 tumorigenesis m6A modification Hnf4α liver damage
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124723007155
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