Impact of high relative dose intensity on effectiveness and treatment continuity of IO-TKI therapy in Japanese advanced renal cell carcinoma

Abstract This study investigated the impact of relative dose intensity (RDI) on the effectiveness and safety of immuno-oncology plus tyrosine kinase inhibitor (IO-TKI) therapy in Japanese patients with renal cell carcinoma (RCC). A total of 145 patients receiving first-line treatment were analyzed:...

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Autori principali:	Yoshihiko Tasaki, Shuzo Hamamoto, Hiroaki Ikoma, Misato Tomita, Takuya Sakata, Hiroko Suzuki, Yusuke Noda, Masayuki Usami, Yohei Tsubouchi, Toshiharu Morikawa, Yoshihisa Mimura, Yosuke Sugiyama, Takashi Nagai, Rei Unno, Toshiki Etani, Taku Naiki, Yoko Furukawa-Hibi, Takahiro Yasui
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Scientific Reports
Soggetti:	Relative dose intensity Immune checkpoint inhibitor Tyrosine kinase inhibitor Renal cell carcinoma Efficacy Adverse event
Accesso online:	https://doi.org/10.1038/s41598-026-43607-4
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