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Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens

Summary: Secreted virulence factors of Toxoplasma to survive in immune-competent hosts have been extensively explored by classical genetics and in vivo CRISPR screen methods, whereas their requirements in immune-deficient hosts are incompletely understood. Those of non-secreted virulence factors are...

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Autori principali: Yuta Tachibana, Emi Hashizaki, Miwa Sasai, Masahiro Yamamoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-06-01
Serie:Cell Reports
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Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124723006034
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