Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance adv...

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Bibliografische Detailangaben

Hauptverfasser:	Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David F. Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, Jr.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2019-06-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	multidrug resistance protein 1 adenosine 5′-triphosphate binding cassette transporter B1 cancer sphingolipid drug therapy sphingosine 1-phosphate
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227520322483
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