KIT-dependent acute myeloid leukemias are responsive to LSD1 inhibition
Abstract Lysine specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent histone demethylase which is overexpressed in acute myeloid leukemias (AMLs). Indeed, several selective LSD1 inhibitors (LSD1is) are currently evaluated in clinical trials. We previously demonstrated that the mammalian target...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2026-05-01
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| Series: | Clinical Epigenetics |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1186/s13148-026-02098-w |
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