A pilot study on therapeutic drug monitoring of asparaginase in Indian children with high-risk ALL: evidence for suboptimal exposure

BackgroundAcute lymphoblastic leukemia (ALL) is the most common childhood malignancy in India, with survival rates (60%–70%) significantly lower than in high-income countries (85%–90%). Asparaginase, a cornerstone of ALL therapy, has a narrow therapeutic window with substantial interpatient pharmaco...

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Autors principals:	Himanshu Dhanda, Shamsuz Zaman, Bhavika Rishi, Raj Kamal, Manpreet Kaur, Nitika Anand, Baseer Noor, Pranay Tanwar, Sufian Zaheer, Prashant Prabhakar, Fouzia Siraj, Amitabh Singh, Aroonima Misra
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Hematology
Matèries:	acute lymphoblastic leukemia (ALL) asparaginase activity chemotoxicity pediatric oncology therapeutic drug monitoring
Accés en línia:	https://www.frontiersin.org/articles/10.3389/frhem.2026.1779396/full
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