Integrated screening identifies GPR31 as a key driver and druggable target for metabolic dysfunction–associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a globally prevalent but intractable disease lacking effective pharmacotherapies. Here, we performed an integrated multilayered screening for pathogenic genes and druggable targets for MASH. We identified the subclass of metabolite-sensing G...

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Váldodahkkit:	Xiao-Jing Zhang, Jiajun Fu, Xu Cheng, Hong Shen, Hailong Yang, Kun Wang, Wei Li, Han Tian, Tian Tian, Junjie Zhou, Song Tian, Zhouxiang Wang, Juan Wan, Lan Bai, Hongfei Duan, Xin Zhang, Ruifeng Tian, Haibo Xu, Rufang Liao, Toujun Zou, Jing Shi, Weiyi Qu, Liang Fang, Jingjing Cai, Peng Zhang, Zhi-Gang She, Jingwei Jiang, Yufeng Hu, Yibin Wang, Hongliang Li
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Clinical Investigation 2025-09-01
Ráidu:	The Journal of Clinical Investigation
Fáttát:	Hepatology Metabolism
Liŋkkat:	https://doi.org/10.1172/JCI173193
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