Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

Autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis (MS) are only partially represented in current experimental models and the development of humanized immune mice is crucial for better understanding of immunopathogenesis and testing of therapeutics. We describe a huma...

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Автори:	Irini Papazian, Maria Kourouvani, Anastasia Dagkonaki, Vasileios Gouzouasis, Lila Dimitrakopoulou, Nikolaos Markoglou, Fotis Badounas, Theodore Tselios, Maria Anagnostouli, Lesley Probert
Формат:	Artigo
Мова:	Inglês
Опубліковано:	eLife Sciences Publications Ltd 2024-06-01
Серія:	eLife
Предмети:	humanized mice multiple sclerosis HLA-DRB1*15 MS risk factor peripheral blood mononuclear cells natalizumab Epstein–Barr virus infection status
Онлайн доступ:	https://elifesciences.org/articles/88826
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