Glucose stimulated CEST MRI pHe mapping for improved differentiation of tumors with altered hypoxia inducible factor 1alpha expression

Abstract Identification of highly aggressive tumors from benign phenotypes is an important diagnostic need, with increased expression of hypoxia-inducible factor-1α (HIF-1α) as one factor linked to tumor progression and treatment response. HIF-1α stabilization is closely linked to extracellular pH (...

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Autori principali:	Aruna Singh, Julia Stabinska, Balaji Krishnamachary, Farzad Sedaghat, Sridhar Nimmagadda, Jeff W. M. Bulte, Zaver M. Bhujwalla, Michael T. McMahon
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-08-01
Serie:	Scientific Reports
Soggetti:	Chemical exchange saturation transfer (CEST) pHe Hypoxia inducible factor-1α (HIF-1α) Iopamidol Breast cancer
Accesso online:	https://doi.org/10.1038/s41598-025-14102-z
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