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Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats

The present study tested the hypothesis that thrombin participates in formation of left atrial remodeling and that direct oral anticoagulants, such as direct thrombin inhibitors (DTIs), can prevent its progression. In a rat model of heart failure associated with left atrial dilation, we found that c...

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Autors principals: Céline Jumeau, PharmD, PhD, Alain Rupin, PharmD, PhD, Pauline Chieng-Yane, PhD, Nathalie Mougenot, PhD, Noël Zahr, PharmD, PhD, Monique David-Dufilho, PhD, Stéphane N. Hatem, MD, PhD
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016-08-01
Col·lecció:JACC: Basic to Translational Science
Matèries:
anticoagulant
atrial arrhythmia
direct thrombin inhibitor
heart failure
remodeling
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2452302X16300304
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