R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling
R-spondins (RSPOs) amplify WNT signaling during development and regenerative responses. We previously demonstrated that RSPOs 2 and 3 potentiate WNT/β-catenin signaling in cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4, 5 and 6 (Lebensohn and Rohatgi, 2018). We now...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications Ltd
2020-05-01
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| Schriftenreihe: | eLife |
| Schlagworte: | |
| Online-Zugang: | https://elifesciences.org/articles/54469 |
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