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β-Lactamase inhibition profile of new amidine-substituted diazabicyclooctanes

The diazabicyclooctane (DBO) scaffold is the backbone of non-β-lactam-based second generation β-lactamase inhibitors. As part of our efforts, we have synthesized a series of DBO derivatives A1–23 containing amidine substituents at the C2 position of the bicyclic ring. These compounds, alone and in c...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Zafar Iqbal, Lijuan Zhai, Yuanyu Gao, Dong Tang, Xueqin Ma, Jinbo Ji, Jian Sun, Jingwen Ji, Yuanbai Liu, Rui Jiang, Yangxiu Mu, Lili He, Haikang Yang, Zhixiang Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2021-03-01
Schriftenreihe:Beilstein Journal of Organic Chemistry
Schlagworte:
amidine
antibacterial activity
β-lactamase inhibitors
diazabicyclooctane
synthesis
Online-Zugang:https://doi.org/10.3762/bjoc.17.60
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