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Targeting metabotropic glutamate receptors for symptomatic and disease-modifying treatment in Parkinson’s disease

Abstract Degeneration of substantia nigra pars compacta dopaminergic neurons is the “hallmark” of Parkinson’s disease (PD) and is responsible for motor signs. Other neurotransmitter systems are responsible for non-motor symptoms that may precede by decades the clinical onset of motor symptoms. The p...

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Bibliografiske detaljer
Principais autores: Marika Alborghetti, Alessia Ceccherelli, Matteo Caridi, Ferdinando Nicoletti, Giuseppe Battaglia, Valeria Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-10-01
Serier:npj Parkinson's Disease
Online adgang:https://doi.org/10.1038/s41531-025-01138-1
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