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A secretory protein neudesin regulates splenic red pulp macrophages in erythrophagocytosis and iron recycling

Abstract Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression. Using 8-week-old neudesin knockout mice, we elucidated the role of neudesin in the spleen. The absence of neudesin caused mild splenomegaly, short...

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Principais autores: Yoshiaki Nakayama, Yuki Masuda, Takehiro Mukae, Tadahisa Mikami, Ryohei Shimizu, Naoto Kondo, Hiroshi Kitagawa, Nobuyuki Itoh, Morichika Konishi
格式: Artigo
语言:Inglês
出版: Nature Portfolio 2024-01-01
丛编:Communications Biology
在线阅读:https://doi.org/10.1038/s42003-024-05802-9
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