Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify <i>O</i>⁶-Alkylated Guanine Bases in DNA

Humans are unavoidably exposed to numerous different mutagenic DNA alkylating agents (AAs), but their role in the initiation of cancers is uncertain, in part due to difficulties in assessing human exposure. To address this, we have developed a screening method that measures promutagenic <i>O</i><sup...

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Principais autores:	Hanum Yaakub, Anthony Howell, Geoffrey P. Margison, Andrew C. Povey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-09-01
coleção:	Toxics
Assuntos:	<i>N</i>-nitroso compounds <i>O</i><sup>6</sup>-alkylguanines Atl1 MGMT slot-blot assay
Acesso em linha:	https://www.mdpi.com/2305-6304/12/9/649
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