Probucol treatment is associated with an ABCA1-independent mechanism of cholesterol efflux to lipid poor apolipoproteins from foam cell macrophages

Objective: Probucol is a cholesterol-lowering agent whose ability to prevent atherosclerosis is currently under study. Herein, we investigate the putative mechanism of probucol by observation of changes in cellular cholesterol efflux and lipid droplet morphology in macrophages. Results: The inhibito...

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Bibliografische Detailangaben

Hauptverfasser:	Anouar Hafiane, MSc, PhD, Alessandro Pisaturo, MSc, Annalisa Ronca, Matteo Incerti, PhD, Robert S. Kiss, PhD, Elda Favari, PhD
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-01-01
Schriftenreihe:	BBA Advances
Schlagworte:	Probucol ABCA1 Apolipoprotein A-I High-density lipoprotein Cholesterol efflux Cholesterol pool
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2667160321000028
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