The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumour microenvironment and opportunities for novel cancer therapeutics

Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue architecture at the cell surface and within the extracellular matrix (ECM). The modification of HSPGs in the tumour microenvironment is known to result not just in structural but also functional consequences whic...

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Prif Awduron:	Edward eHammond, Ashwani eKhurana, Viji eShridhar, Keith eDredge
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2014-07-01
Cyfres:	Frontiers in Oncology
Pynciau:	cancer therapy Heparan sulfate Heparanase tumor microenvironment targeting SULF1 Sulf2
Mynediad Ar-lein:	http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00195/full
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