A synergistically freeze-enzymatically crosslinked silk fibroin hydrogel for sustained kartogenin delivery and enhanced cartilage regeneration

Articular cartilage repair remains challenging because of limited intrinsic regeneration and the need for sustained mechanical and biological support. We developed a silk fibroin (SF) scaffold combining directional freezing with HRP/H2O2-mediated enzymatic crosslinking. The resulting EF-SF hydrogel...

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Autores principales:	Xiangshu Guo, Jianqi Xiong, Wei Li, Shengjia Chen, Lin Yao, Junjie Deng, Pianpian Zheng, Longxing Niu, Rong Wang, Shaolin Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-09-01
Colección:	Materials & Design
Materias:	Silk fibroin Freeze Hydrogel Kartogenin Articular cartilage regeneration
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0264127526013080
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