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DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter

DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-). RB1 encodes a tumour suppressing, cell cycle regul...

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Autori principali: AM Raizis, HM Racher, A Foucal, H Dimaras, BL Gallie, PM George
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2021-09-01
Serie:Epigenetics
Soggetti:
epimutations
dna hypermethylation
loop extrusion
ctcf
rb1
promoter
retinoblastoma
cancer
Accesso online:http://dx.doi.org/10.1080/15592294.2020.1834911
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