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Comparative Transcriptome Analysis Demonstrates the Positive Effect of the Cyclic AMP Receptor Protein Crp on Daptomycin Biosynthesis in Streptomyces roseosporus

Daptomycin, which is produced by Streptomyces roseosporus, has been characterized as a novel cyclic lipopeptide antibiotic that is effective against Gram-positive bacteria. The biosynthesis of daptomycin is regulated by various factors. In the present study, we demonstrated that the cyclic AMP recep...

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Principais autores: Jiequn Wu, Danqing Chen, Jinrong Wu, Xiaohe Chu, Yongmei Yang, Lina Fang, Wei Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-06-01
Serier:Frontiers in Bioengineering and Biotechnology
Fag:
daptomycin
cyclic lipopeptide antibiotic
Streptomyces roseosporus
NRPS
Crp
transcriptional regulator
Online adgang:https://www.frontiersin.org/articles/10.3389/fbioe.2021.618029/full
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