Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice

<p>Abstract</p> <p>Background</p> <p>Despite decades of intense research efforts, actions of acute opioids are not fully understood. Increasing evidence suggests that in addition to well-documented antinociceptive effects opioids also produce paradoxical hyperalgesic and excitatory effects on neuron...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Liu Yen-Chin, Berta Temugin, Liu Tong, Tan Ping-Heng, Ji Ru-Rong
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	SAGE Publishing 2012-03-01
Rangatū:	Molecular Pain
Ngā marau:	Dorsal root ganglion Metalloprotease MMP-9 mu opioid receptor (MOR) Opioid-induced analgesia Opioid-induced hyperalgesia (OIH) Spinal cord
Urunga tuihono:	http://www.molecularpain.com/content/8/1/19
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!