Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors

ABSTRACT This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon‐γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, poten...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae, Kyle McHugh, Zhuangrong Huang, Eric Hodgman, Michael C. Borys, Julia Ding, Gloria Li, Anthony Leone
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Maximum Academic Press 2025-01-01
سلاسل:	Engineering in Life Sciences
الموضوعات:	µSIA continuous bioprocessing FIA labs monoclonal antibody (mAb) process analytical technology (PAT) quality by design (QbD)
الوصول للمادة أونلاين:	https://doi.org/10.1002/elsc.202400031
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!