FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways

FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies. Here we report, for the first time, the anti-melanogenic efficacy of FGIN-1-27 in vitro and in vivo. FGIN-1-27 si...

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Bibliographic Details

Main Authors:	Jinpeng Lv, Songzhou Jiang, Ying Yang, Ximei Zhang, Rongyin Gao, Yan Cao, Guoqiang Song
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2020-12-01
Series:	Frontiers in Pharmacology
Subjects:	FGIN-1-27 human epidermis melanocytes SK-MEL-2 cells melanogenesis protein kinase A/cAMP-responsive element-binding protein kinase C-β
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.602889/full
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