Identification of a heparin-binding domain in the distal carboxyl-terminal region of lipoprotein lipase by site-directed mutagenesis

The interaction of lipoprotein lipase (LPL) with heparan sulfate proteoglycans plays an important role in the metabolism and catalytic function of the enzyme. We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405,...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Rebecca A. Sendak, André Bensadoun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 1998-06-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	heparin-Sepharose chromatography Chinese hamster ovary cells discontinuous binding region
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227520325578
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!