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The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways

Introduction: Growing evidence has shown the correlation between periodontitis and atherosclerosis, while our knowledge on the pathogenesis of periodontitis-promoting atherosclerosis is far from sufficient. Objectives: Illuminate the pathogenic effects of Fusobacterium nucleatum (F. nucleatum) on in...

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Principais autores: Song Shen, Tianyong Sun, Xiangjiu Ding, Xiufeng Gu, Yushang Wang, Xiaomei Ma, Zixuan Li, Haiting Gao, Shaohua Ge, Qiang Feng
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2024-03-01
סדרה:Journal of Advanced Research
נושאים:
Fusobacterium nucleatum
Lipid deposition
Gbp
CypA
RNA-seq
Drug repositioning
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2090123223001133
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