The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin

Huntington's disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT). PolyQ expansion promotes misfolding and aggregation of mutant HTT (mHTT) within neurons. The cellular pathways, including ubiquitin-dependent proc...

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Ngā kaituhi matua:	Bo Wang, Li Zeng, Sean A. Merillat, Svetlana Fischer, Joseph Ochaba, Leslie M. Thompson, Sami J. Barmada, Kenneth M. Scaglione, Henry L. Paulson
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2018-01-01
Rangatū:	Neurobiology of Disease
Ngā marau:	Huntington's disease Huntingtin Ubiquitination Ubiquitin-conjugating enzyme Ube2W Protein misfolding
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S096999611730222X
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!