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Parkin coregulates glutathione metabolism in adult mammalian brain

Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn with Sod2 haploinsufficiency in mice. Although adu...

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Auteurs principaux: Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Ajanta Chatterji, Angela P. Nguyen, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal Pileggi, Chet E. Holterman, Bojan Shutinoski, Juan Li, Travis K. Fehr, Matthew J. LaVoie, Rajiv R. Ratan, Gary S. Shaw, Masashi Takanashi, Nobutaka Hattori, Christopher R. Kennedy, Mary-Ellen Harper, Arne Holmgren, Julianna J. Tomlinson, Michael G. Schlossmacher
Format: Artigo
Langue:Inglês
Publié: BMC 2023-01-01
Collection:Acta Neuropathologica Communications
Sujets:
Early-onset Parkinson disease
Parkin
Prkn
Sod2
Redox stress
Glutathione metabolism
Accès en ligne:https://doi.org/10.1186/s40478-022-01488-4
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