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Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesis

IntroductionThe heterogeneity of outcomes after Mycobacterium tuberculosis (Mtb) exposure is a conundrum associated with millennia of host-pathogen co-evolution. We hypothesized that human myeloid cells contain genetically encoded, Mtb-specific responses that regulate critical steps in tuberculosis...

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Principais autores: Hyejeong Hong, Kimberly A. Dill-McFarland, Jason D. Simmons, Glenna J. Peterson, Penelope Benchek, Harriet Mayanja-Kizza, W. Henry Boom, Catherine M. Stein, Thomas R. Hawn
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-03-01
Serier:Frontiers in Immunology
Fag:
Mycobacterium tuberculosis
expression quantitative trait loci
monocyte response
proinflammatory cytokine
host-pathogen interactions
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359178/full
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