Trim7 aggravates ischemic stroke–associated ferroptosis by promoting ubiquitin-mediated degradation of HSPA5

Abstract Objective Ischemic stroke is a leading cause of neurological disability and death worldwide, posing a substantial threat to human health. Tripartite motif-containing protein 7 (Trim7), an E3 ubiquitin ligase, is involved in the progression of various diseases, but its role in ischemic strok...

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Hlavní autoři:	Wenxuan Lu, Sha Hu, Wenhui Zhang, Ruiqiang Wang, Dongxu Zhao, Peng Ji, Peng Zhang, Yilin Zhang, Huili Gao, Ziliang Wang, Tianxiao Li, Zhigang Lu, Zhaoshuo Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-10-01
Edice:	Cell & Bioscience
Témata:	Trim7 Stroke HSPA5 Ferroptosis Ubiquitination
On-line přístup:	https://doi.org/10.1186/s13578-025-01476-w
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