Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice

Abstract Background Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive emerging treatment strategy for AD. We address the que...

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Bibliografische Detailangaben

Hauptverfasser:	Helen Crehan, Bin Liu, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Kevin X. Le, Barbara J. Caldarone, Jeffrey L. Frost, Thore Hettmann, Birgit Hutter-Paier, Brian O’Nuallain, Mi-Ae Park, Marcelo F. DiCarli, Inge Lues, Stephan Schilling, Cynthia A. Lemere
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2020-01-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Pyroglutamate-3 amyloid-β Immunotherapy APPSWE/PS1ΔE9 Phagocytosis Microhemorrhage microPET
Online-Zugang:	https://doi.org/10.1186/s13195-019-0579-8
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