Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function

A group of intrinsically disordered proteins (IDPs) are subject to 20S proteasomal degradation in a ubiquitin-independent manner. Recently, we have reported that many IDPs/IDRs are targeted to the 20S proteasome via interaction with the C-terminus of the PSMA3 subunit, termed the PSMA3 Trapper. In t...

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Egile Nagusiak:	Marianna Riutin, Pnina Erez, Julia Adler, Assaf Biran, Nadav Myers, Yosef Shaul
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2024-10-01
Saila:	Cells
Gaiak:	ubiquitin-independent degradation CDKN1A and p21WAF1/Cip1 degradation 20S proteasome targeting
Sarrera elektronikoa:	https://www.mdpi.com/2073-4409/13/19/1670
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