Neurosteroid [3α,5α]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway

BackgroundPrevious studies demonstrated the inhibitory effect of allopregnanolone (3α,5α-THP) on the activation of inflammatory toll-like receptor 4 (TLR4) signals in RAW264.7 macrophages and the brains of selectively bred alcohol-preferring (P) rats. In the current study, we investigated the impact...

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Auteurs principaux:	Irina Balan, Adelina Grusca, Todd K. O’Buckley, A. Leslie Morrow
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-12-01
Collection:	Frontiers in Endocrinology
Sujets:	[3α,5α]-3-hydroxy-pregnan-20-one (3α,5α-THP) [3α,5α]-3,21-dihydroxypregnan-20-one (3α,5α-THDOC) toll-like receptor 4 toll/interleukin-1 receptor domain-containing adapter-inducing interferon-β (TRIF) neuroinflammation
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1299420/full
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