The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

For three decades, the LPL–specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LPL, and prevent the propensity of concentrated LPL preparations to form...

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Autori principali:	John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2020-10-01
Serie:	Journal of Lipid Research
Soggetti:	antibodies lipid metabolism protein structure triglycerides X-ray crystallography
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520437022
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