Monitoring of Nutrients, Metabolites, IgG Titer, and Cell Densities in 10 L Bioreactors Using Raman Spectroscopy and PLS Regression Models

<b>Background:</b> Chinese hamster ovary (CHO) cell metabolism is complex, influenced by nutrients like glucose and glutamine and metabolites such as lactate. Real-time monitoring is necessary for optimizing culture conditions and ensuring consistent product quality. Raman spectroscopy has emerged a...

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Autors principals:	Morandise Rubini, Julien Boyer, Jordane Poulain, Anaïs Berger, Thomas Saillard, Julien Louet, Martin Soucé, Sylvie Roussel, Sylvain Arnould, Murielle Vergès, Fabien Chauchard-Rios, Igor Chourpa
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-04-01
Col·lecció:	Pharmaceutics
Matèries:	Raman spectroscopy process analytical technology (PAT) CHO cell culture bioprocess monitoring chemometric analysis IgG titer prediction
Accés en línia:	https://www.mdpi.com/1999-4923/17/4/473
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