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Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

Abstract Background Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methylation are common in HGSOC. Differences in DNA met...

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Principais autores: Tushar Tomar, Nicolette G. Alkema, Leroy Schreuder, Gert Jan Meersma, Tim de Meyer, Wim van Criekinge, Harry G. Klip, Heidi Fiegl, Els van Nieuwenhuysen, Ignace Vergote, Martin Widschwendter, Ed Schuuring, Ate G. J. van der Zee, Steven de Jong, G. Bea A. Wisman
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-06-01
Serier:BMC Medicine
Fag:
DNA methylation
Integrated methylome analysis
Ovarian cancer
Platinum-based chemotherapy
Extreme chemoresponders
Online adgang:http://link.springer.com/article/10.1186/s12916-017-0870-0
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