MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition.

Advanced lung cancer has poor survival with few therapies. EGFR tyrosine kinase inhibitors (TKIs) have high response rates in patients with activating EGFR mutations, but acquired resistance is inevitable. Acquisition of the EGFR T790M mutation causes over 50% of resistance; MET amplification is als...

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Bibliografiske detaljer

Principais autores:	Elena Ortiz-Zapater, Richard W Lee, William Owen, Gregory Weitsman, Gilbert Fruhwirth, Robert G Dunn, Michael J Neat, Frank McCaughan, Peter Parker, Tony Ng, George Santis
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2017-01-01
Serier:	PLoS ONE
Online adgang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170798&type=printable
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