Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block

Summary: A gain-of-function mutation in the Ca2+-activated transient receptor potential melastatin member 4 (TRPM4A432T) is linked to life-threatening cardiac conduction disturbance, but the underlying mechanism is unclear. For deeper insights, we used photolysis of caged Ca2+, quantitative Ca2+, an...

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Prif Awduron:	Wenying Xian, Xin Hui, Qinghai Tian, Hongmei Wang, Alessandra Moretti, Karl-Ludwig Laugwitz, Veit Flockerzi, Sandra Ruppenthal, Peter Lipp
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2018-07-01
Cyfres:	Cell Reports
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2211124718309446
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!