HHLA2 as an emerging immune checkpoint in lung cancer: linking EGFR signaling, macrophage polarization, and CD8+ T-cell metabolic suppression

Immune checkpoint blockade has revolutionized the treatment of lung cancer; however, therapeutic responses remain heterogeneous, particularly in patients harboring activating epidermal growth factor receptor (EGFR) mutations. Emerging evidence identifies human endogenous retrovirus-H long terminal r...

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Detalhes bibliográficos

Principais autores:	Juan Wang, Kang Wang, Zhenhong Hu, Xueting Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Immunology
Assuntos:	EGFR-mutant lung cancer HHLA2 KIR3DL3 T-cell metabolism tumor-associated macrophages
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1815639/full
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