Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Abstract Neural tube defects (NTDs) are one of the most common congenital malformations. Folic acid deficiency in pregnant women increases the risk of developing NTDs; however, the underlying etiology and mechanisms remain elusive. In this study, the role of DNA double‐strand breaks (DSBs) in 3D gen...

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Бібліографічні деталі
Автори:	Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2025-12-01
Серія:	Advanced Science
Предмети:	3D genome DNA double‐strand breaks folic acid high‐throughput chromosome conformation neural tube defects
Онлайн доступ:	https://doi.org/10.1002/advs.202410603
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Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

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