A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5 -year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types of cancers, including pancreatic cancer, however poor so...

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Detalhes bibliográficos

Principais autores:	Qiaomu Tian, Peng Zhang, Yihan Wang, Youhui Si, Dengping Yin, Christopher R Weber, Melissa L Fishel, Karen E Pollok, Bo Qiu, Fei Xiao, Anita S Chong
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2023-10-01
coleção:	eLife
Assuntos:	triptolide pancreatic cancer drug development apotosis
Acesso em linha:	https://elifesciences.org/articles/85862
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