Tyrosine bioconjugation using stably preparable urazole radicals

Our ex situ tyrosine bioconjugation method utilizes the oxidation of N-methylurazole by Bobbitt's salt or electrochemical activation to generate stable radicals for selective tyrosine labeling, thereby addressing the longstanding challenges in protein bioconjugation. Unlike traditional tyrosine conj...

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Autors principals:	Shinichi Sato, Shogo Miyano, Keita Nakane, Zhengyi Liu, Munehiro Kumashiro, Tomohide Saio, Yuya Tanaka, Akira Shigenaga, Chizu Fujimura, Eri Koyanagi, Hafumi Nishi, Shusuke Tomoshige, Minoru Ishikawa
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-12-01
Col·lecció:	Tetrahedron Chem
Matèries:	Tyrosine Bioconjugation Radicals Protein chemical labeling Chemical proteomics
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2666951X24000500
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