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Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects

Background: The incidence of intervertebral disc degeneration (IVDD) is a common degenerative disease with inflammation, decreased autophagy, and progression of fibrosis as its possible pathogenesis. Physalin A (PA) is a widely studied anti-inflammatory drug. However, its therapeutic effects on IVDD...

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Hlavní autoři: Rui Lu, Haoran Xu, Xiaofeng Deng, Yingguang Wang, Zhiyi He, Shimeng Xu, Shuang Liang, Xiaojian Huang, Hongbo You, Fengjing Guo, Peng Cheng, An-min Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-03-01
Edice:Journal of Orthopaedic Translation
Témata:
Intervertebral disc degeneration
Physalin A
Inflammation
Autophagy
Fibrosis
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2214031X23000013
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