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The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types, including prostate cancer (PCa). Both KDM1A and...

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Principais autores: Veronika M. Metzler, Simone de Brot, Daisy B. Haigh, Corinne L. Woodcock, Jennifer Lothion-Roy, Anna E. Harris, Emeli M. Nilsson, Atara Ntekim, Jenny L. Persson, Brian D. Robinson, Francesca Khani, Kristian B. Laursen, Lorraine J. Gudas, Michael S. Toss, Srinivasan Madhusudan, Emad Rakha, David M. Heery, Catrin S. Rutland, Nigel P. Mongan, Jennie N. Jeyapalan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-04-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
epigenetics
splicing
transcriptional regulation
KDM-inhibitors
histone modification
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2023.1116424/full
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