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GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina

Using constitutive GRF1/2 knockout mice, we showed previously that GRF2 is a key regulator of nuclear migration in retinal cone photoreceptors. To evaluate the functional relevance of that cellular process for two putative targets of the GEF activity of GRF2 (RAC1 and CDC42), here we compared the st...

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Principais autores: David Jimeno, Concepción Lillo, Pedro de la Villa, Nuria Calzada, Eugenio Santos, Alberto Fernández-Medarde
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-11-01
Serier:Cells
Fag:
cone photoreceptor
GRF2
CDC42
RAC1
nuclear movement
cell death
Online adgang:https://www.mdpi.com/2073-4409/12/21/2574
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