Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade

Monoclonal antibodies that target the inhibitory immune checkpoint axis consisting of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have changed the immune-oncology field. We identified K2, an anti-human PD-L1 single-domain antibody fragment, that can enhance T cell activation and tu...

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Detalhes bibliográficos

Principais autores:	Robin Maximilian Awad, Quentin Lecocq, Katty Zeven, Thomas Ertveldt, Lien De Beck, Hannelore Ceuppens, Katrijn Broos, Yannick De Vlaeminck, Cleo Goyvaerts, Magali Verdonck, Geert Raes, Alexander Van Parys, Anje Cauwels, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-09-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	programmed death-ligand 1 single domain antibody nanobody gene therapy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050121001017
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