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Automated, scaled, transposon-based production of CAR T cells

Background There is an increasing demand for chimeric antigen receptor (CAR) T cell products from patients and care givers. Here, we established an automated manufacturing process for CAR T cells on the CliniMACS Prodigy platform that is scaled to provide therapeutic doses and achieves gene-transfer...

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Principais autores: Mario Assenmacher, Andrew Kaiser, Michael Hudecek, Razieh Monjezi, Matthias Eyrich, Dominik Lock, Caroline Brandes, Stephan Bates, Simon Lennartz, Karin Teppert, Leon Gehrke, Rafailla Karasakalidou-Seidt, Teodora Lukic, Marco Schmeer, Martin Schleef, Niels Werchau, Sabrina Prommersberger, Thomas Schaser
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2022-09-01
coleção:Journal for ImmunoTherapy of Cancer
Acesso em linha:https://jitc.bmj.com/content/10/9/e005189.full
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